The best time to take domperidone is about 15-30 minutes before meals. Domperidone is a drug that promotes gastrointestinal motility, mainly used for abdominal distension, belching, nausea, vomiting and food reflux, acid reflux and other discomfort caused by gastrointestinal tract dysfunction, but also for gastroenteritis, poor diet and nausea, vomiting and other discomfort caused by malignant tumors after radiotherapy. After entering the body, the drug can directly block the peripheral dopamine receptors, increase the tone of the lower esophageal sphincter, enhance gastric peristalsis, promote emptying, prevent gastroesophageal reflux, coordinate gastric and duodenal movements, thus achieving the suppression of nausea and vomiting symptoms, and effectively prevent bile reflux without affecting gastric juice secretion. Its absorption and onset of action takes about 15-30 minutes. Taking the drug in advance coincides with the time of eating, which helps to empty the food in the gastrointestinal tract and alleviate the discomfort symptoms. In addition, patients should also note that domperidone should not be taken together with drugs that inhibit stomach acid and should not be taken for a long time to avoid liver damage.