Pregnancy has no effect on syphilis infection, but the pregnancy rate is significantly lower in syphilis patients. About 23%-40% of women with active syphilis are infertile, and the infertility rate is 1-5 times higher than normal. The causes of infertility are related to genital lesions, especially the occurrence of tubal inflammation and endometritis affecting pregnancy, but despite this, syphilis patients of childbearing age still have a pregnancy rate of 1.5%-8%. However, pregnancy is prone to preterm delivery, miscarriage, and stillbirth. In the first 4 months of pregnancy, the embryo is proliferating and does not lay in the uterus, so the fetus is not infected in the first 4 months of pregnancy. If syphilis is cured during this period, the risk of fetal distress increases due to the J.H reaction caused by the treatment, but the occurrence of stillbirth is extremely rare, and the necessary treatment should not be postponed for fear of stillbirth.