It is possible that taking atorvastatin may cause headache discomfort. Atorvastatin is mainly taken in people with hypercholesterolemia accompanied by macrovascular disease, such as cerebrovascular stenosis and stroke, etc. Patients with these diseases may also experience headache due to the disease itself. Different people may react differently to atorvastatin and may experience gastrointestinal discomfort, allergy, elevated transaminases, myalgia, etc. If a patient has headache, it is recommended to go to the hospital promptly and follow the medical advice to improve head CT, head MRI and other related examinations to clarify the presence of cerebrovascular lesions.