How does cervical cancer occur?

  The cervix is located at the lower end of the uterus and is thin and long cylindrical. Among female malignant tumors in China, the incidence rate of cervical cancer ranks second after breast cancer, with 130,000 to 150,000 new cases each year. The age of prevalence is 40-60 years old, with an average age of 50 years old. Unfortunately, in recent years, there is a trend of increasing the number of patients at the age of presentation.  The development of cervical cancer is mainly associated with an infection called human papillomavirus. The DNA of this virus can integrate into the genome of the host cell, causing mutations in the cervical epithelium and consequently malignant transformation.  In addition to HPV infection, cervical cancer is also related to some other factors: 1. Marriage and childbirth factors Epidemiological surveys show that people who marry early and have sex too early have a higher risk of cervical cancer. For example, the incidence of cervical cancer is lowest among those who have given birth 1-3 times in their lifetime, and the incidence increases gradually among those who have given birth 4-6 times and significantly among those who have given birth more than 7 times.  For example, the incidence rate of those who have more than 3-5 sexual partners is higher than those who have only one sexual partner, and the relative risk of those who have 10 or more sexual partners is more than 3 times higher than those who have only one sexual partner or no sexual partners. In addition, if a partner is circumcised or circumcised, the foreskin may contain carcinogens, which are also associated with the development of cervical cancer. Since Jews are circumcised at birth, penile cancer is rare among men and cervical cancer is also extremely rare among women.  Chronic cervical cancer patients such as chronic cervicitis, cervical erosion, cervical polyps, mucosal leukoplakia and cervical cancer are also correlated to some extent. It is possible that these diseases such as chronic inflammation have synergistic carcinogenic effect with cell carcinogenesis.  4.Smoking It has been proved that nicotine in tobacco has carcinogenic effect, and nicotine can be detected in cervical cancer mucus. Therefore, although smoking is not a separate risk factor for cervical cancer, it has a synergistic effect with other carcinogenic factors, especially for women who smoke heavily for a long time, its carcinogenic effect cannot be excluded.  The occurrence and development of cervical cancer has a gradual process, starting with mild atypical hyperplasia of cervical epithelial cells, then to moderate and severe hyperplasia, and then developing to carcinoma in situ, early invasive carcinoma to invasive carcinoma. In fact, early detection of cervical cancer is very easy, as long as a cytology smear is performed, more than 90% of people can determine whether there are cell abnormalities. At this time, preventive or therapeutic measures are extremely effective.