The old saying that disease enters through the mouth is very true. Throughout one’s life, one eats many kinds of food, but many people have no major diseases throughout their lives, indicating that the body’s ability to resist is extremely strong; however, there are always foods, especially uncommon foods, that the body eats and then has some problems, even if they are not immediate problems, and some people may gradually show these related diseases years or even a dozen years later. Today we are ready to talk about liver fluke infection. Clinically, we often encounter patients with bile duct cancer and cholangitis combined or not with obstructive jaundice who, upon examination, are found to have liver fluke infection, or worse, discharged liver fluke worms that can be seen one after another in the bile duct drains. All of these patients, without exception, had eaten freshwater fish, some a few years ago, others more than a decade ago, or even longer. Schistosoma haematobium infection, also known as Schistosoma chinensis infection. The reason it is called liver fluke is that after eating raw freshwater fish or shrimp infected with Schistosoma haematobium, the larvae can enter the biliary system through the digestive tract and adhere to the bile duct epithelium. These changes are related to the number of infections, the duration of infection, whether the infection is repeated, and the sensitivity of the individual. According to the results of the survey, the prevalence of liver fluke in the populations of Heilongjiang, Guangxi, Hainan and Guangdong provinces is probably greater than 1%, with Guangdong Province dominated by the Pearl River and Han River tributaries. So, in addition to eating freshwater raw fish may be infected with liver fluke, with liver fluke raw fish after sun-drying, salt curing and other treatment, will not be infected? The answer is: it is possible to be infected. Therefore, the most important thing is to cook it and eat it. Also, does the use of wasabi as a condiment reduce the risk of infection? The results of an interesting study tell us that “green wasabi spice has a stimulating and mild killing effect on liver fluke cysts, but no killing effect in a short period of time, so it is not advisable to expect the use of wasabi spice to kill liver fluke cysts to achieve prevention of liver fluke infection.” Some of you may also ask if there is any risk of liver fluke infection by eating Japanese sashimi (さしみ saximi). According to my own experience, this is less likely. Seeing this, some of you who have eaten freshwater raw fish and shrimp before may want to ask, what should I do? It is recommended to check the fecal liver fluke egg count at the hospital. Generally, liver fluke eggs can be detected in the feces about 4 weeks after eating raw fish infected with liver fluke.