The survival period of primary liver cancer cannot be generalized, but depends on the clinical stage at the time of diagnosis, treatment measures and underlying diseases. As the last part of the “liver disease trilogy”, primary liver cancer often occurs after viral hepatitis and cirrhosis, with insidious onset and is mostly detected in the middle and late stages. If detected early and the mass is still small, it can be surgically removed and the prognosis is better, with a 5-year survival rate of about 70%. If the lump is not large when liver cancer is detected, but the degree of cirrhosis is more serious, it also affects the survival time. In some patients, liver cancer is more malignant and progresses rapidly, so the survival time is correspondingly shorter. For patients with primary liver cancer, treatment should not only fight for treatment opportunities but also avoid over-treatment. Encouraging patients to maintain a positive life attitude to cooperate with treatment is important for disease control.