The clinical manifestations of osteoporosis are pain, such as back pain and leg pain in the elderly, in addition to deformity, which is mainly manifested by hunchback and shortening of height, and most seriously leads to fracture, the most common in the elderly is lumbar compression fracture causing pain; femoral neck fracture and thigh root fracture, all of which cause painful manifestations to patients. Clinically calcium and vitamin D supplementation are the most essential nutritional supplements for osteoporosis or osteoporotic fractures. There are two main drug treatments for pain, as follows: 1. Bisphosphonates, on the basis of calcium and D supplementation, choose bisphosphonates, such as oral alendronate, or intravenous order ibandronate or zoledronic acid, the application of this drug can inhibit bone resorption and reduce bone pain; 2. Calcitonin, the most commonly used is salmon calcitonin, or eel calcitonin, calcitonin is to promote the free calcium in the blood to deposit on the bone. At the same time, there is a central opioid receptors, to reduce the patient’s pain. However, we should pay attention to the course of use of these two types of drugs, such as the oral alendronate of bisphosphonates, to a certain period of treatment will enter the drug holiday. After entering the drug holiday, bone density and other analyses should be performed to assess the condition and then choose another sequential treatment method.