Diabetic nephropathy generally consists of five stages: glomerular hyperfiltration stage, no clinically manifested kidney damage stage, early diabetic nephropathy stage, clinical diabetic nephropathy stage, and end-stage renal failure. Diabetic nephropathy is preventable, and as long as kidney damage can be detected early and reasonably protected, the process of diabetic nephropathy will be delayed. Although Liu has been suffering from diabetes for many years, he does not have a good understanding of diabetes and the common sense of easy complications of nephropathy. So, be alert if you have the following symptoms! 1. Protein in the urine. Patients are often asked when they go to the doctor, “Is there much foam in the urine?” This is the result of diabetes damage to the glomerulus and other microvasculature, the phenomenon of urine protein appears intermittently in the early stage, and appears after exercise. If it is not present at rest but appears after exercise or if the urine protein increases further, it is called exercise-type proteinuria. At present, the early detection of diabetic nephropathy is mostly done clinically by checking urine microalbumin (random urine check for urine microalbumin or urine albumin to urine creatinine ratio). If patients have urine microalbumin, it indicates early diabetic kidney damage, and treatment should be strengthened to slow down the development of diabetic nephropathy. 2. Increased nocturia. Patients will also be asked by doctors, “Do you urinate a lot at night?” (Nocturnal polyuria does not mean more urination, but more urination at night than during the day or more than 750ml at night). Increased nocturia is due to impaired renal tubular function and indicates that the kidneys have been involved. Normal people urinate more during the day than at night. When the renal tubules are damaged, the concentration function decreases and increased nocturia occurs. 3.If diabetic patients show symptoms such as edema, hypertension and anemia, it indicates that diabetic nephropathy has developed to a more serious degree. This is may have reached the diabetic V stage, and renal replacement therapy should be performed as soon as possible.