With the maturity of liver transplantation technology, it has become one of the most effective treatments for end-stage liver disease, and many patients are familiar with this treatment method from unfamiliarity, but the question that always confuses many patients is “when to start? At present, the internationally recognized indicators for liver transplantation are: 1. more than one ruptured esophagogastric variceal bleeding; 2. refractory ascites; 3. recurrent hepatic encephalopathy; 4. hepatorenal syndrome; 5. spontaneous peritonitis; 6. albumin level below 28g/L; 7. total bilirubin of 171-342umol/L with a tendency to increase; 8. prolonged prothrombin time of 5s or more. . The lighter the preoperative condition, the lower the intraoperative surgical risk and the better the postoperative recovery, and vice versa, so do not wait until the “end of the road”.