Treat depression as you would treat a cold or other illness, go to the hospital openly and proactively, and seek the help of a doctor who can help you solve your pain sooner without having to suffer and without triggering serious consequences. When you have depression, the most taboo point is to think that depression is your own problem and “carry on”. Imagine that you can recover through your own regulation or efforts, in fact, this is basically impossible. Because depression is a disease, on the surface it is a problem of emotions. Etiologically speaking, its appearance involves many functional and structural changes in the brain. For example, alterations in the concentration of neurotransmitters that regulate neurotransmission. In general, the preferred treatment for depression is treatment with antidepressants. As long as you cooperate with your doctor and take the medication consistently, the effect is certain. Some patients may have an “immediate” effect, usually within a week or two, and three or four weeks can receive very good results. If you take a week or two, you feel that the effect does not work, then do not eat, or ask the doctor to change the drug, in fact, this approach is wrong, first of all, each person’s physique is not exactly the same, in addition to the regulation of the drug on the brain needs a process, the process is generally two to three weeks, it is not possible to take the drug the next day the disease is cured. When taking antidepressants, we should also pay attention to the principle of “adequate treatment, sufficient dose, and sufficient course of treatment”. After 4-6 weeks of treatment, the acute depression will be relieved, but further maintenance treatment is needed. This is because of the high recurrence rate of depression. About 75% of patients whose first depressive episode is in remission have the possibility of relapse. Therefore, prevention of depression is an important part of our treatment. The effective way to prevent relapse is to continue consolidation and maintenance treatment. This has been proven by many medical practitioners in clinical studies over a period of more than one year. In our experience, the duration of preventive medication is usually 4 to 6 months after the depression is cured. The recommendation of the WHO Expert Advisory Group is that treatment should be maintained for at least 6 months after the first depressive episode is cured; 2 to 3 years after the second episode is cured; and when the third episode occurs, lifelong medication should be considered. Of course, in clinical practice, we have to take into account the patient’s age, the number of episodes, the severity of the disease, the presence of family history, adverse drug reactions, compliance with medication and the convenience of taking medication. Numerous experiences tell us that the longer the maintenance of treatment for depression patients, the lower the relapse rate.