Klebsiella pneumoniae is a well known pathogen that causes hospital-acquired infections. Most community-acquired Klebsiella pneumoniae infections usually cause pneumonia or urinary tract infections. However, in the last two decades, liver abscess invasive syndrome caused by this bacterium has been reported in several places in Asia and has gradually become a global disease. This review summarizes the clinical presentation, treatment, and microbiological features of this invasive disease. When diabetes mellitus is combined with two specific podococcal bacterial infections, patients are more likely to develop abscesses in the liver and to develop the following metastatic complications: bacteremia, meningitis, endophthalmitis, and necrotizing fasciitis. In patients with this aggressive syndrome, appropriate antimicrobial therapy combined with percutaneous liver abscess drainage may improve survival. Rapid detection of highly virulent strains of this invasive syndrome can facilitate early diagnosis and treatment to minimize the incidence of sequelae and improve clinical outcomes.