Tiny thyroid nodules may disappear. Nodules smaller than 0.5 centimeters may be treated with thyroxine tablets in small doses when the thyroid function test is normal. In some patients, the nodules may disappear, leading to a cure. The diagnosis of thyroid nodules, a very common disease of the thyroid gland, depends on the ultrasound grading of thyroid nodules, which is used for further evaluation and treatment. When thyroid nodules are below grade 3, they are usually considered to be mostly or almost always benign and have a very low probability of malignancy.