Recently, Associate Professor Wen Yu of the Department of Hepatobiliary and Pancreatic Surgery of our hospital successfully performed a case of “total laparoscopic pancreatic tail resection with preservation of spleen”. The patient recovered well without any complications and was successfully discharged 6 days after surgery. The patient, a 27-year-old female, was admitted to the hospital for “3+ months of caudal pancreatic body occupancy found on physical examination”. The abdominal CT showed a 5 cm diameter cystic hypodense shadow in the caudal part of the pancreatic body, which was closely related to the splenic hilum and splenic vessels. The patient’s cosmetic requirements were high and she wanted to have the lesion removed by minimally invasive surgery, so she went to several tertiary hospitals in the province. After consultation with professors of general surgery and thorough preoperative preparation, under the guidance of Prof. Miao Xiongying and Prof. Huang Shengfu, the chief of the department, Associate Professor Wen Yu revealed the tumor in the body of the pancreas caudally and found that the tumor was 5 cm in diameter, cystic in nature and adjacent to the splenic vein and splenic hilum. The tumor was found to be 5 cm in diameter, cystic in nature and adjacent to the splenic vein and the splenic hilum. A combination of blunt and sharp methods was used to separate the tumor from the splenic vessels and ligated the vascular branches entering the pancreas branch by branch. According to the main surgeon, Associate Professor Wen Yu, the blood vessels supplying the spleen pass in the upper posterior part of the pancreas and have a close relationship with the pancreas, and also send out many branches to supply the tail of the pancreatic body on the way, so the traditional operation of the tail of the pancreas requires the removal of the spleen together. Recent studies have shown that the spleen is the largest immune organ in the body, and it plays an important role in anti-tumor, anti-infection, and immune regulation, so it is increasingly important to preserve the spleen during surgery. For benign or low malignant pancreatic tail tumors, effective preservation of the spleen poses a higher requirement for surgeons, especially when this difficult surgery is performed under total laparoscopy, which is a challenge, as a slight mistake can lead to tearing of splenic vessels, causing intraoperative hemorrhage and endangering patients’ lives. The completion of this surgery marked a new level of pancreatic lumpectomy in our hospital, filling the gap in this field in the province and providing useful exploration to promote the development of laparoscopic technology to safer and more difficult.