High alkaline phosphatase can be caused by liver disease, by normal physiological conditions, or by other diseases such as biliary tract disorders and endocrine disorders. Alkaline phosphatase is an enzyme distributed in human tissues such as liver, bone, intestine, kidney and placenta. Physiologically, it is elevated mainly in relation to bone growth, development, maturation, pregnancy and postprandial secretion of fats. Pathologically, it can be seen in liver diseases, such as hepatitis, cirrhosis, etc.; it can also be seen in biliary system diseases, such as intrahepatic cholestasis, bile duct obstruction caused by bile duct stones, etc.; and it can also be seen in bone diseases, such as rickets, osteochondritis dissecans, fibrositis ossificans. In addition, severe anemia, malnutrition, colonic ulcer, heavy metal poisoning, etc., can also cause high alkaline phosphatase. Endocrine diseases, such as primary or secondary hyperthyroidism and tumors that can produce bone destruction, can cause high alkaline phosphatase. If high alkaline phosphatase is detected, it should be taken seriously, and prompt medical attention should be given to identify the cause of the disease and further management or treatment as prescribed by the doctor.