Duodenal ulcers may cause back pain, mainly due to perforation and nerve involvement pain caused by the ulcer itself. Typical symptoms of duodenal ulcer are regular epigastric pain, which can be dull, burning, distending, etc. Most of them are hunger pain and nocturnal pain, and the pain can be relieved after eating, accompanied by acid reflux and heartburn, loss of appetite, belching, etc. If the ulcer site adheres to the posterior peritoneum, peritoneal perforation can cause back pain, and serious perforation can cause gastrointestinal hemorrhage, which is life-threatening. Duodenal ulcers are usually examined under gastroscopy by taking tissue biopsy and performing H. pylori examination. For those who have cardiovascular and cerebrovascular comorbidities and cannot undergo endoscopy, barium meal X-ray examination can be used, which usually has characteristic manifestations such as niche shadow and irritation sign. In case of duodenal ulcer, antacid drugs and drugs to protect the gastric mucosa can be used as basic treatment. In case of perforation, gastrointestinal decompression can be performed first, waiting for the small hole to heal and close on its own, and in case of severe bleeding, surgical hemostasis is required. In addition, in daily life, patients should pay attention to the regularity of life, avoid overwork and mental tension, eat less spicy and stimulating food, such as chili, mustard, garlic, etc., and quit smoking and alcohol.