Depression is currently the most common mental illness, and the incidence has been gradually increasing in recent years, the latest statistics in China’s lifetime prevalence rate is 6%, while some foreign countries statistics reached 20%, this difference does not necessarily reflect the true situation, one of the reasons is that due to cultural reasons, the national stigma and avoidance of mental illness is more serious than abroad, some patients do not go to the doctor or even conceal the disease from the survey statisticians. Therefore, no statistics were done. The main clinical manifestations are: depressed mood, sadness all day long, reluctance to go out and meet people, loss of interest, negative and pessimistic, spending their days like years, many patients have the concept of suicide and behavior, some patients are accompanied by insomnia, anxiety and irritability, etc. The most dangerous consequence of depression is suicide, and some patients fail to commit suicide, resulting in disability, but in fact, many patients with depression can be clinically cured through treatment, and in turn, looking back on their behavior at that time, it is very worthless. In the face of this situation, it is recommended to popularize mental health knowledge and to seek timely medical attention once similar symptoms are detected in relatives or people around you, as well as to abandon the stigma of mental illness and seek timely medical attention in regular specialized hospitals to minimize the damage as much as possible. Illness is something that cannot be chosen, but how to face it is up to you, and different attitudes lead to different outcomes.