Microwave ablation treatment for liver cancer does not require incision, is less invasive, has precise efficacy, significantly prolongs survival and improves patients’ quality of life, and the tumor-free survival rate of liver cancer patients has increased from 10% to more than 30%, which has brought gospel to the majority of liver tumor patients. Microwave ablation combined with radioactive particle implantation for the treatment of liver cancer, which is a key project of Guangdong Provincial Science Association Cooperation, has been successfully implemented in our hospital for more than 1 year and has achieved good clinical results. Among the treated cases, there are patients with advanced tumor who cannot be operated, or those who are in poor physical condition or too old to tolerate surgery, or those who cannot be operated after tumor recurrence, and there are even some patients who refuse to accept open surgery but accept this procedure, all of them have achieved satisfactory clinical results, and the longest case has survived for more than one year. The longest case has survived for more than one year. The surgical resection rate of middle and advanced liver cancer is only about 5%-10%, while the surgical mortality rate is more than 10%. Microwave ablation is a minimally invasive procedure to treat tumors. Under the guidance of CT image, the microwave antenna needle is directly punctured to the liver tumor site through a tiny 2 mm needle hole in the patient’s abdominal skin. Due to the effect of high frequency electromagnetic wave, the liver tumor tissue containing charged particles, water molecules and other polar molecular substances oscillate in high frequency and generate heat by friction with each other, reaching a high temperature of 60-100 degrees Celsius, causing coagulative necrosis of tumor tissue in the ablation area, and the necrotic tissue is absorbed and replaced by new liver tissue without affecting liver function. Moreover, the ablation time of microwave is short and the effect on the whole body is small, most of the tumor ablation time is about 10-15min, and multiple points can be superimposed as appropriate, so that the ablation range extends beyond the lesion area to 1.0cm or more of normal tissues to ensure full necrosis of tumor tissue. Due to the features of low tissue damage, no incision, minimally invasive, precise effect, wide indications, easy acceptance by patients and fast recovery, this technique can be widely applied to all kinds of primary liver cancer, metastatic liver cancer and other occupying lesions, and it is also applicable to recurrent liver cancer with poor general condition, which greatly improves patients’ survival and quality of life, and will definitely bring a new page to the treatment of liver cancer. It will bring a brand new page to the treatment of liver cancer.