Brain metastasis refers to metastatic tumors in the brain. These diseases are all malignant tumors, including multiple intra-parenchymal brain metastases as well as meningeal metastases, which cause more severe headaches and require the use of strong analgesic drugs. Currently, tramadol and depot tablets are more commonly used. Non-steroidal analgesics such as ibuprofen and naproxen are not effective, and if the pain is severe, morphine or pethidine can also be used. The use of pain medication alone cannot completely relieve the patient’s symptoms, but also requires a combination of dehydrating and cranial pressure lowering drugs, such as mannitol, glycerol fructose, sodium heptaerythrone, furosemide, torasemide, etc. If necessary, small doses of hormones can be used to help reduce edema, commonly used dexamethasone. The headache can be relieved within a short period of time after the edema of brain cells is reduced and the intracranial pressure is lowered, but the primary disease should also be treated, and neurosurgery can be considered for those who have indications for surgery, while radiotherapy or chemotherapy should be combined with the nature of the primary tumor for those who do not have indications for surgery.