Laziness: Sudden fatigue and weakness for no reason, feeling lazy and incompetent, even lazy to cope with daily life, simple work or household chores. Dullness: Decreased movement, dull and passive actions, slow thinking, difficulty in thinking, decreased memory and attention, significantly reduced comprehension and brain function. Change: Significant change in personality, and the difference between before and after 4. Worry: Melancholy and pessimism, depression, lack of confidence and vitality, and a feeling of losing everything. Depression, bitterness, lack of interest in all things outside, and feel a lot of physical discomfort. Fifth, worry: thoughtful and anxious, anxious and restless, fidgety, or at a loss, often self-blame, and low self-esteem. In general, there can be a long time to cure, or insomnia of unknown cause, for weeks or even months. It is an important sign of depression. Some people with depression may feel unwell, but a physical examination will show that they are completely healthy physically. 75% of depression is caused by various mental stresses. Former British Prime Minister Winston Churchill called depression the “black dog” and told the public from personal experience: “If the ‘black dog’ starts to bite you, don’t ignore it, and if the severe signs have been going on for weeks and there are If the serious signs have lasted for weeks and there are suicidal thoughts, then it’s time to see a psychiatrist.” The latest international medical research shows that a relative or absolute deficiency of serotonin-centered brain “5-hydroxytryptamine” is an important cause of depression, so depression should be treated with active and effective antidepressants, and combined with psychotherapy, will gradually restore the health of depressed patients.