During the acute attack of gout, the principle of treatment is to rapidly relieve joint swelling and pain and to prevent recurrent attacks, and the commonly used drugs are non-steroidal anti-inflammatory analgesics, colchicine and glucocorticoids. During the acute attack of gout, it is recommended that anti-inflammatory and analgesic treatment should be carried out as early as possible (generally within 24 hours), among which non-steroidal anti-inflammatory and analgesic drugs should be the first choice, such as etoricoxib, diclofenac sodium, celecoxib and loxoprofen sodium, etc. However, attention should be paid to the cardiovascular and gastrointestinal adverse effects of drugs. Colchicine is also very commonly used in the acute phase of gout, but because of its high incidence of gastrointestinal adverse reactions, and it is easy for patients to stop taking it because they cannot tolerate it, colchicine is currently used only for patients in the acute phase of gout who have contraindications to the use of nonsteroidal anti-inflammatory analgesics. If the patient’s condition is severe and conventional drug treatment is not effective, or if there are contraindications to the use of both NSAIDs and colchicine, short-term use of glucocorticoids can be considered to control the symptoms. Therefore, for patients in the acute stage of gout, the commonly used drugs are non-steroidal anti-inflammatory analgesics, colchicine and glucocorticoids, but no matter what kind of drugs are used, they need to visit the rheumatology department first and develop a treatment plan under the guidance of a doctor, and they need to pay attention to adverse drug reactions while using them, follow up regularly and follow up on discomfort.