Patients often have the illusion that herbal medicines are safe, have no side effects and can be used for a long time. So, are herbal medicines really safe? Can herbal medicines also cause liver damage to the liver? It is reported that there are more than 1000 kinds of drugs known to cause liver damage, nearly 50% of which are caused by herbal medicines, herbal medicines cause liver damage can no longer be ignored. Severe drug-related liver damage can develop into acute and subacute liver necrosis, and the mortality rate is very high. So, what are the main herbs that cause drug-related liver damage? Broadly speaking, they can be divided into the following categories: 1, to general liver damage: long-term or overdose of ginger, pu huang, mulberry, mountain cicada, etc.. 2, to toxic liver damage: overdose of neem, huang yaozi, castor bean seeds, lei gong teng decoction, etc. Long-term use of rhubarb or intravenous infusion of seasons injection may interfere with the bilirubin metabolic pathway and lead to jaundice. 3, induce liver tumor: earthwort, calamus, anise, pepper, bee’s head tea, millipede and other herbs contain safrole ether; green wood, mucuna pruriens, saltpeter, vermilion, etc. contain nitro compounds, all may induce liver cancer. 4. Chinese patent medicines that may cause liver damage: Strong Bone and Joint Pills, Noma Jie San, Ke Yin Pills, Dissipative Silver Tablets (Pills), Zeng Sheng Ping, Rumex Pills, Shan Hai Tang, Yin Qi San, Liushen Pills, Shu Feng Ding Pain Pills, Damp Poison Qing, Anti-ringworm Ning, Fang Feng Tong Sheng Pills, Blood Poison Pills, Dehumidifier Pills, Dragon Snake and Wind Chaser Capsules, Strong Bone and Tendon Capsules, Nourishing Blood and Tendon Capsules, Nine Dispersions, Chasing Wind and Bone Pills, Bone and Immortality Tablets, Methoprene Capsules, Women’s Health Tablets, Huayu Pills Pills, Blood Nourishing and Hair Growth Capsules, Shou Wu Tablets, Shuang Huang Lian Oral Liquid, Yin Qiao Tablets, Fu Fang Gan Lu Drink, Niu Huang Detoxification Tablets, Ge Gen Tang, Ma Heng Shi Gan Tang, etc. How to avoid drug-related liver injury caused by Chinese herbs? It is a medicine with three toxins, and herbal medicine is no exception. Avoid taking herbal medicine blindly if not necessary. Before clinical use, patients should also be familiar with the side effects of the herbs used and their clinical manifestations, and should not apply them for a long time or in large quantities. For those who have pre-existing liver disease and really need to use herbal medicine that is damaging to the liver for treatment, they should follow medical advice and start with small doses and check liver function regularly. In the process of treating non-liver diseases with drugs, liver function should also be checked regularly, especially when symptoms such as loss of appetite, weakness, abdominal distension, pain in the liver area and jaundice appear, whether there is drug-related liver damage should be considered and should not be paralyzed, and the original use of drugs should be stopped and a specialist hospital for liver disease should be consulted.