In recent years, the incidence of syphilis has risen to the first place among sexually transmitted diseases, and every day there are newly discovered and diagnosed syphilis patients in outpatient clinics, so more and more patients are consulted and treated for syphilis. Syphilis is a sexually transmitted disease, which is caused by infection with the syphilis spirochete. It can not only damage the skin, mucous membranes and genitals, but can also spread throughout the body through the bloodstream, causing serious damage to multiple organs throughout the body, especially the nervous system, bones, cardiovascular system, eyes, liver, gallbladder, kidneys, intestines and other systems, causing irreversible lesions in many places and even death in severe cases. Pregnant women infected with syphilis can also transmit it directly to the fetus through the placenta, causing miscarriage, premature birth or death of the fetus. Therefore, syphilis is a chronic infectious disease that is extremely dangerous. Syphilis is transmitted in the following ways: syphilis patients are the only source of infection, and there are a large number of syphilis spirochetes in the patient’s broken skin, blood, semen, saliva, and lotion, so more than 95% of patients are infected through sexual contact, including normal sex, anal sex, and oral sex. The second mode of transmission is vertical transmission, that is, syphilis pregnant women through the placenta and umbilical vein directly to the fetus, the third mode of transmission is other ways, including direct contact transmission, blood transfusion, breastfeeding, broken skin mucous membrane, mouth-bite kissing and other infections, health care workers can be infected due to hand trauma. Indirect contact transmission includes sharing needles, razors, clothing, towels, bottles, toilets, toothbrushes, cigarettes, medical equipment, etc. This method is rare and only theoretically possible. Therefore, syphilis is still transmitted mainly by sexual contact, blood transfusion and peptide transmission, but general life contact, such as eating, shaking hands, hugging is not infectious.