Uneven echogenicity in breast nodules is due to mastopexy. Mammary gland hyperplasia nodules are caused by endocrine disorders resulting in imbalance of estrogen and progesterone secretion. Excessive secretion of estrogen stimulates follicle and breast duct hyperplasia, while the protective function of progesterone decreases, resulting in mammary gland hyperplasia, which causes the formation of mammary gland nodules. Since some patients have follicular hyperplasia of the breast that becomes apparent as a cystic structure, the patient has an uneven internal echogenicity of the breast nodule, a condition called cystic hyperplasia of the breast, which is a common benign clinical hyperplasia. It occurs especially in middle-aged women between 30 and 50 years of age, and the incidence of mammary hyperplasia increases significantly. Especially in patients with uneven internal echogenicity, the possibility of malignant transformation is about 2%-3%, so female patients with breast hyperplasia should be followed up regularly, once a year after the age of 40.