Abstract: Objective To summarize the clinicopathological characteristics and surgical treatment experience of infective endocarditis combined with periaortic valve abscess. METHODS The clinical data of 29 patients with infective endocarditis combined with periaortic valve abscess treated surgically in our hospital from January 2001 to June 2013 were retrospectively analyzed. RESULTS: Of the 29 patients in the group, 22 were male and 7 were female; the mean age was 36.6±16.3 years (11-63 years), of which 16 (55.2%) had congenital aortic valve malformation as the underlying cardiac disease, 22 (75.9%) had class III-IV cardiac function, 15 (51.7%) had a history of heart failure, 19 had positive bacteriological cultures of blood or intraoperative tissue There were 19 positive blood or intraoperative tissue bacteriological cultures, and 9 cases of Staphylococcus aureus (47.4%). The location of the abscess was above the annulus in 14 cases (48.3%), below the annulus in 10 cases (34.5%), and both above and below the annulus in 5 cases (17.2%); simple abscesses in 8 cases (27.6%), pseudoaneurysms in 13 cases (44.8%), intracardiac ventricular fistulas in 6 cases (20.7%), and severe infections forming aortic left ventricular dissection in 5 cases (17.2%). There were 19 cases of perivalvular defect repair by patch, 10 cases of direct suture, 16 cases of simultaneous annular reconstruction, 26 cases of simple aortic valve replacement, 2 cases of BENTALL operation, 23 cases of artificial mechanical valve and 5 cases of biological valve. 28 cases were cured and discharged, and 1 case died of sepsis after surgery. There was no recurrence of endocarditis or perivalvular leakage in one case. Conclusion: Infective endocarditis combined with periaortic valve abscess is not uncommon and prone to heart failure, and a satisfactory surgical outcome can be achieved by selecting a suitable surgical approach according to different anatomical features.