Can anti-hepatitis B virus treatment be stopped without authorization? –We have too many cases of liver failure due to rebound of Hepatitis B virus after discontinuing antiviral therapy on our own. In an extreme case, a patient who forgot to bring his medication after traveling for 7 days during the 11th Golden Week came back to the hospital in great discomfort, and was later hospitalized with a new liver. Of course, not everyone is so unlucky, but certainly not everyone is “Mr. Lucky”, the chance of misfortune must be extremely high. Including my patient. How do I choose a medication to continue treatment after unauthorized discontinuation of anti-hepatitis B virus? Based on guidelines and literature, patients whose HBV-DNA is below the lower limit of detection at the time of discontinuation can be retreated with either the original regimen or a combination of nucleoside analogs with no cross-resistance sites. Some patients ask since anti-hepatitis B virus treatment is concerned about long-term, then take a long time to eat without laboratory tests? No. Regular review, follow-up, monitoring of liver and kidney function, hepatitis B markers, hepatitis B viral load, alpha-fetoprotein, abdominal imaging, etc., as well as regular checkups for hepatitis B drug resistance-related tests, etc. are required. Although the consensus on the endpoint of antiviral therapy in the global hepatitis B treatment guidelines is not uniform, and even if the endpoint of discontinuation recommended by the current guidelines is reached, there is still the problem of viral rebound or even hepatitis relapse after discontinuation of the drug, but medical science must be rigorous and objective.