Pain in only one ankle is not necessarily gout, but can also be seen in other conditions such as prolonged cold, sprains, prolonged standing, osteoarthritis, etc. The main clinical symptoms during the acute attack of gout are redness, swelling, heat, pain and mobility disorders of the joints. If one ankle pain occurs and gout is suspected, uric acid needs to be checked to clarify the cause. In addition, one ankle pain can also be caused by other factors, such as long-term cold in the ankle, which can also lead to ankle pain; if the ankle joint is repeatedly sprained, it can cause traumatic arthritis of the ankle joint, which can lead to pain; it can also be caused by osteoarthritis or rheumatic or rheumatoid arthritis and other diseases. Therefore, pain in only one ankle is not necessarily gout, and needs to be differentiated from other conditions. If the diagnosis of gout is clear, patients should avoid walking with weight, elevate the affected foot to promote venous return and reduce swelling and pain, take non-steroidal drugs for anti-inflammation and analgesia, and pay attention to low purine diet, quit smoking and alcohol, and drink water to promote uric acid excretion.