Can extrahepatic metastasis of hepatocellular carcinoma recur?

  Postmortem examination of patients with hepatocellular carcinoma showed an incidence of extrahepatic metastases of 64%. The incidence of extrahepatic recurrence of hepatocellular carcinoma after radical resection was about 9.7% to 25.8%, which may be related to the difference in follow-up time and sample selection. The mean time to extrahepatic recurrence after surgery was 7-13 months, of which 38% were accompanied by intrahepatic recurrence.  The lungs were the most common organ for extrahepatic metastases, accounting for approximately 55% of all extrahepatic metastases, followed by abdominal lymph nodes (41%), bone (28%), and adrenal glands (11%). Bilateral lung metastases are equally common, but are more common in the lower lobe than in the upper lobe; 28% of these lung metastases are combined with metastases to other organs. Periceliac nodes account for 33% and porta-hepatic nodes for 23% of the abdominal lymph node metastases. Bone metastases were common in the spine, with 22% in the thoracic spine and 15% in the lumbosacral spine. Other uncommon metastatic sites include the oral cavity, jaws, septal sinus, butterfly sinus, testes, ovaries, and stomach.  The extrahepatic metastatic pathways of hepatocellular carcinoma mainly include blood, lymphatic fluid and direct infiltration and implant metastasis, and multiple metastases can occur simultaneously. Organs such as lung, bone, and adrenal gland. It may be the result of metastasis by blood route (about 56% of extrahepatic metastasis), the proportion of metastasis by lymphatic system is about 26.7% , infiltrative metastasis by adjacent organs such as mediastinum and gallbladder is about 21.8%.