There are no clinically authoritative relevant medical studies to prove whether long-term antidepressant medication can be used to administer the New Crown vaccine. There is also no clear contraindication to long-term antidepressant medication as a contraindication to vaccination with the New Crown vaccine. However, it is not recommended to vaccinate patients with major depressive disorder or those who are in acute depressive episodes that are more difficult to control.1. Although there are no clear experimental studies to show that antidepressants can react with the vaccine, if patients who have been taking antidepressants for a long time are vaccinated with the New Crown vaccine while taking the medication, the two may affect each other to reduce the efficacy of the medication, making it difficult for the antidepressants to achieve their previous effects and also affecting the protective effect of the vaccine. The protective effect of the vaccine on the human body may also have some impact on the safety and reliability of the New Crown vaccine; 2. Patients who have been taking antidepressants for a long time prove that they have certain impairment in mental, emotional, and basic social interaction functions, and need to take medication to reach the level of ordinary people. Some people will have abnormal manifestations such as drowsiness, fever, sleepiness and weakness after the injection of New Crown vaccine. At this time, for such patients, the vaccine injection will aggravate the restlessness and is not conducive to maintaining the stability of the disease. Therefore, patients suffering from moderate or severe depression, or those in acute depressive episodes, can hold off the timing of the New Crown vaccination and wait until the symptoms of depression are relieved or cured before consulting a professional doctor and considering the vaccination.