The specific medication for the treatment of high uric acid depends on the patient’s etiology and condition. The saturation and concentration of uric acid in the body at 37°C is about 420 μmol/L (7 mg/dl), and over this concentration is hyperuricemia. The main clinical drugs for lowering uric acid are: 1. Uric acid excreting drugs: the mechanism of these drugs is to inhibit the reabsorption of uric acid salts in the proximal renal tubules, thus increasing the excretion of uric acid and lowering the level of uric acid. These drugs are suitable for people with good kidney function, and they should drink more water and take sodium bicarbonate 3~6g/d. Commonly used drugs are: benzbromarone. 2.Inhibit uric acid production drugs: The mechanism of these drugs is that allopurinol reduces uric acid production by inhibiting xanthine oxidase, which is suitable for those who have excessive uric acid production or are not suitable for using uric acid excreting drugs. The dose should be reduced in patients with renal insufficiency and prohibited in patients with G5 stage of renal insufficiency (uremic phase). 3.Alkaline drugs: sodium bicarbonate can alkalize the urine, so that uric acid is not easy to gather in the urine to form crystals. 4.New uric acid-lowering drugs: ①Uric acid oxidase: decompose uric acid into soluble products and discharge. ②Selective uric acid reabsorption inhibitor. In addition to drug treatment should also pay attention to its general treatment, so as to achieve better therapeutic effect. Then patients with hyperuricemia should also pay attention to controlling total dietary calories; limiting alcohol consumption can high intake of high purine food; drinking a lot of water to increase uric acid excretion; cautiously using drugs that inhibit uric acid excretion such as thiazide diuretics; avoiding triggering factors and actively treating related diseases. Therefore, high uric acid should be treated reasonably with the cooperation of diet and drugs as a whole, and under the guidance of clinicians.