Depression is an affective disorder mental illness characterized by depressed mood, slow thinking and reduced and flaccid speech and movement, which is generally classified as a mood disorder in Western medicine. According to relevant data, depression has become the second largest disease burden among people aged 15-44 in the world, most of whom are in the working age, bringing great losses to individuals, families and society. around 2000, a survey report from 11 cities in Jiangxi showed that the point-in-time prevalence of depression was 0.95%, and the total prevalence was as high as 1.15%. Moreover, with the accelerated pace of life in modern society and the increasing competition, the prevalence rate is increasing year by year. Clinical manifestations 1, depressive episodes are clinically based on depressed emotions, slowed thinking, reduced volitional activity and physical symptoms. Depressed mood: the main manifestation is significant and persistent depressed mood, easy to pessimism. Patients are worried, depressed, sad, and sighing all day long. Lack of interest in everything, the usual hobby activities such as watching soccer games, playing cards, planting flowers, etc. also feel boring, anything can not raise the spirit. Severe cases can be painful, pessimistic and desperate, with the feeling that life is like a year and life is worse than death. Typically, patients may also experience more severe symptoms in the morning and less severe symptoms in the evening. Patients may also experience slowed thinking and association, slow reaction time, closed thinking, reduced active speech, and significantly slower speech speed. In addition, patients live a passive, lazy life, do not want to do anything, do not want to contact with the surrounding people, often live alone behind closed doors, alienate friends and relatives, avoid social interaction. In terms of physical symptoms, the main manifestations are sleep disturbance, loss of appetite, weight loss, loss of libido, constipation, pain in any part of the body, impotence, amenorrhea, and weakness. Patients with geriatric depression may also have anxiety and irritability, hypochondria, loss of appetite, bloating, constipation, etc. 2, bad mood Refers to a mild depression dominated by a persistent state of depressed mood, never manic. It is often accompanied by anxiety, somatic discomfort and sleep disturbance. Most of the time, patients feel heavy and depressed, look at things as if wearing a pair of sunglasses, the surrounding area is bleak, no interest in work, no enthusiasm, lack of confidence, pessimistic and disappointed about the future, often feel depressed, fatigue, reduced ability, etc.. Despite this, the patient’s work and study and social function are not significantly impaired, and often have self-awareness, they know they are in a bad mood and take the initiative to request treatment. Second, clinical treatment 1, Western medicine often have antidepressants Selective 5-HT reuptake inhibitors (SSRIs): such as fluoxetine, paroxetine, sertraline and citalopram; norepinephrine and 5-HT dual uptake inhibitors (SNRIs): such as venlafaxine; NE and specific 5-HTergic antidepressants (NaSSAs): such as mirtazapine; tricyclic and tetracyclic Antidepressants, such as mipramine, amitriptyline and doxepin; monoamine oxidase inhibitors. Modern clinical use of Dexedrine is a combination of two common and proven highly effective compounds. Flupirtine is a thiazide neuroblocker with anxiolytic and antidepressant effects in small doses. Melitrexin is a biphasic antidepressant with euphoric properties when applied at low doses. It has the same pharmacological effects as amitriptyline, but has a weaker sedative effect. The combination of the two ingredients has antidepressant, anxiolytic and euphoric properties. However, side effects such as dry mouth, constipation, blurred vision and tremors, insomnia, anxiety and sexual dysfunction are common with western drugs. Some patients also suffer from a certain degree of dependence. Find a kind of side effects, the efficacy of the exact and easy to use therapy special bag drug treatment will be the future development trend. 2.Chinese medical treatment for depression Chinese medical treatment often uses Chinese herbal medicine therapy as the main treatment, can be combined with acupuncture and other methods to treat depression. Through evidence-based treatment, the overall treatment of the patient’s disease, can achieve the regulation of the patient’s internal organs qi and blood dysfunction, improve the depression symptoms, reduce or stop taking Western medicine effect. It is an ideal alternative therapy to Western medicine and is the current development trend of depression treatment. More and more patients choose Chinese medical treatment at the initial stage of the disease, which has important clinical significance in improving clinical symptoms, improving quality of life, and reducing the adverse side effects of Western medicine. In conclusion, patients with depression should be aware of their disease, actively cooperate with clinical treatment, and choose Western and Chinese medical treatments as needed. To be confident in the treatment of the disease, adjust the mentality, do things positively, adhere to the treatment and be optimistic, they will definitely overcome the disease and regain a healthy and happy life.