Syphilis is a chronic sexually transmitted disease caused by infection with the pale spirochete. After infection, the spirochete can spread throughout the body, invade multiple organs throughout the body, and produce lesions. It can also be latent for many years or even for life without clinical manifestations. Syphilis can also be transmitted from the mother to the fetus through the blood of the placenta, resulting in premature birth, death, or the delivery of a baby born with syphilis. Syphilis can be classified by its source of transmission as acquired syphilis (acquired) or congenital syphilis. Acquired syphilis is a long-term disease with symptoms that may or may not appear due to changes in the body’s resistance and responsiveness. It can be generally divided into one, two or three stages. The first stage is the chancre stage; the second stage is the rash stage, collectively called early syphilis, which is highly infectious; the third stage is the late stage, which is less infectious. Stage I syphilis: After 2-4 weeks of incubation period after unclean sexual contact and spouse or indirect infection, the main skin manifestation is hard chancre. The hard chancre is 1-2 cm in diameter, round or oval with slightly elevated edges and a flesh-red central vesicular surface or potential ulcer. It is not painful or itchy, and is usually found on the external genital area, but also on the anus, lips, breasts, fingers, etc. Stage II syphilis: Onset within 2 years after infection, usually occurs 7-10 weeks after infection or 6-8 weeks after the appearance of hard chancre. The rash is polymorphic, often generalized and symmetrical, and usually not painful or itchy. It may be accompanied by mild discomfort or generalized superficial lymph node enlargement. Laboratory tests: A serological test for syphilis (non-syphilis spirochete antigen test RPR and syphilis spirochete antigen test TPPA or TPHA) is required.