Syphilis is a chronic, systemic sexually transmitted disease caused by infection with the syphilis spirochete. The early syphilis can be cured by penicillin treatment, and syphilis is basically not contagious after it is cured or after two years of onset. The examination items of syphilis mainly include syphilis serology test, syphilis spirochete antibody test, dark field microscopy, molecular biology syphilis test and cerebrospinal fluid examination. The syphilis serological test is mainly performed by mixing the patient’s serum with a special unheated Benzidine Red Page 1 and placing it in a shaker, and making a diagnosis by observing whether there is a granular agglutination. Syphilis spirochete anti-Hugh test is performed by injection of immunoglobulin. Dark field microscopy is a pathogenic test and is of great importance for the diagnosis of early syphilis. Molecular biology syphilis test mainly uses specific probes to perform the test, which greatly improves the diagnostic rate. Cerebrospinal fluid examination is mainly applicable to patients with advanced syphilis and the appearance of neurological symptoms. In addition to the need for effective treatment, syphilis patients also need to pay extra attention to their diet, eat more fresh vitamin-rich vegetables and fruits, eat less cold, hard, greasy and stimulating food, quit smoking and alcohol, and should also drink more water to promote the elimination of toxins from the body through urine coating.