Syphilis can be cured if detected early and treated actively, and usually does not affect the patient’s life expectancy. Some patients with more serious lesions, untimely treatment and poor results may have their survival time affected, which may vary from several years to decades depending on individual circumstances. If such lesions are found or suspected to be present, prompt medical consultation is required to make a clear diagnosis, and the diagnosis of syphilis should be followed up regularly in addition to active treatment. The first stage of syphilis is mainly hard chancre, which is 1-2cm in diameter, single round or oval lesion, mostly found in the external genital area, and within 1 year most of the patients’ serum reaction can turn negative, which can be cured and does not affect the life expectancy. Stage II rash has more forms and types, but after recurrence, it usually shows limited lesions, with larger lesions and fewer numbers, and most patients can be seronegative within 2 years. Stage III is dominated by dendritic swelling, and if neurosyphilis is present, the cerebrospinal fluid should be examined every six months until it completely turns normal. This stage usually results in severe organ damage and can affect the patient’s life expectancy, but the survival time for each individual needs to be judged on a case-by-case basis and there is no uniform standard. Syphilis is usually treated with medication, usually with antibiotics such as penicillin and tetracycline, and some patients can be cured. The disease is usually contracted through sexual transmission, but can also be transmitted through the placenta or blood, so patients should take strict protective measures when having sex. In case of female patients, strict contraception should also be observed to avoid transmission to the next generation. If you are pregnant, you should seek medical advice and let your doctor determine the specific situation and take the correct treatment. In the case of newborns, the disease usually develops within 2 years of age, or after 2 weeks in severe cases, but there is usually no obvious manifestation at birth, so parents should be vigilant.