Gilbert et al. analyzed 66 discontinuation studies, 29 of which included a control group of schizophrenic patients maintained on antipsychotics with a mean follow-up of 10 months and a mean relapse rate of 53% in discontinued patients compared to 16% in the maintenance group. Dr. John F Greden emphasized that more than half of patients with chronic illnesses such as schizophrenia relapse exactly within the first 10 months after discontinuing their medication, and after more than two years of follow-up, the percentage of relapse in discontinued patients was as high as 80%, while the risk of relapse in maintenance patients was 15% within 10 months and 30% after more than 2 years of follow-up. Relapse rates have been found to be relatively low during the first year of first-episode schizophrenia, with a significant increase in relapse rates after one year. Delbert Robinson et al. studied 108 patients with first-episode schizophrenia or schizoaffective disorder who were followed up after recovery. 104 patients completed at least two months of follow-up, with an equal number of male and female patients and a mean age of 25.6 ± 6.3 years. The cumulative first relapse rate over 5 years was 81.99%; the second relapse rate was 78.0%; and the third relapse rate was 86.2% within 4 years after the second relapse, with a nearly 5-fold increase in the risk of relapse when antipsychotic medication was discontinued. It is concluded that patients with first-episode schizophrenia and schizoaffective disorder have a high relapse rate within 5 years after recovery, and maintenance medication treatment can reduce the risk of relapse. Patients cured after the first relapse who are not effectively monitored have a high rate of second and third relapse, and discontinuation of antipsychotic treatment significantly increases the risk of relapse.