Portal vein embolization is a new technique developed only in recent years. Its principle is to block the portal vein that provides blood supply to the cancer side through portal vein embolization, so that the blocked blood flows to the opposite side, increasing the blood supply and blood pressure of the opposite liver, prompting the compensatory enlargement and hypertrophy of the opposite liver to meet the needs of the organism, and then remove the huge liver cancer after a certain period of time, so that the residual liver can work normally and meet the needs of the organism after surgery. This can ensure that the residual liver can work normally and meet the needs of the organism after surgery, avoid the occurrence of liver failure, and enable many patients with liver cancer that cannot be removed directly to receive effective treatment. At present, there are very few hospitals in China that perform this technique. Since this technology has been carried out in our hospital, we have achieved very good results. The following is one of the cases, which is introduced as follows: Huang Gang, Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Guangzhou Medical University Patient Chen, male, 75 years old. He was admitted to the hospital in April 2012 due to “right upper abdominal pain for more than one month”. The patient had been positive for hepatitis B virus for more than 10 years without any discomfort, regular checkups, or antiviral treatment. The patient developed right upper abdominal pain with no obvious cause more than one month ago, mainly distension. He went to Guangzhou for examination and treatment. Due to the severe cirrhosis leading to liver atrophy, both were considered inoperable and inoperable for interventional treatment. After coming to our hospital, we found that the patient had a huge hepatocellular carcinoma of the right liver (150*140mm), severe cirrhosis and hepatic atrophy, and the volume of the left liver was less than 30% of the whole liver, so if the right half of the liver was removed surgically, the remaining left liver could not compensate and would definitely cause liver failure. Likewise, interventional treatment could not be tolerated. After a thorough and detailed analysis, it was decided to perform right portal vein embolization. After portal vein embolization, the patient’s left liver was compensated and enlarged, and the right hepatocellular carcinoma was reduced. After examination and evaluation, the right hepatocellular carcinoma could be surgically removed. After being admitted to the hospital for relevant examination and liver protection, the right hemicolectomy was performed under general anesthesia in May 2012. Intraoperatively, we could see more clear yellowish ascites in the abdominal cavity, severe cirrhosis, pineapple-shaped nodules on the edge and surface of the liver, compensatory hypertrophy of the left lobe, severe varices of the splenic hilar vessels, and obvious varices of the esophagogastric fundus. The right hepatic hepatocellular carcinoma was successfully resected. Due to precise and meticulous surgery with little damage and bleeding, the patient recovered rapidly. He was discharged from the hospital in good condition.