High bilirubin in liver function test should be taken seriously, which may indicate that the liver’s uptake and bile excretion functions have problems and abnormal liver function. We should start from the following aspects to regulate: 1, for the cause of treatment and regulation. First of all, we should find out the cause of the disease. There are many diseases that cause high bilirubin, such as hepatitis, hepatocellular carcinoma, cirrhosis, cholelithiasis, hemolytic anemia and so on. If the jaundice is caused by bile duct obstruction, minimally invasive surgical treatment can be carried out to relieve the biliary obstruction. For example, if the obstruction is caused by choledocholithiasis, according to the size and location of the stone, surgery or endoscopic stone removal can be used, and at the same time, combined with the application of medicines such as lithotripsy or lithotripsy, etc, to prevent the recurrence of the stone. Only by targeting the cause of the disease and actively removing the primary disease, can the production and metabolism of bilirubin be normalized. 2.Pharmacological conditioning treatment. For high bilirubin body will usually show jaundice symptoms, such as skin, eyes yellow, yellow urine, etc., you can apply medication to reduce yellowing treatment conditioning. 3, diet and life adjustment: daily life attention to ensure intestinal nutrition, drink more water, eat more fresh fruits and vegetables, to achieve balanced nutrition in moderation, dietary advice to refer to the “Dietary Guidelines for Chinese Residents”, to improve the body’s immunity. Pay attention to the combination of work and rest, do not stay up late, quit smoking and alcohol, develop good habits, and maintain an optimistic state of mind. High bilirubin should not be ignored, should be timely medical to identify the cause, targeted treatment of the cause of the disease, for non-pathological high to do from the diet and lifestyle habits to adjust.