Early syphilis is usually very effective in 3-4 weeks after the injection. However, syphilis needs to be observed for 2-3 years from the beginning of treatment, and a serological review should be performed every 3 months in the first year after regular treatment. Observe the treatment of the disease, if the control is better, in the 2nd-3rd year every 6 months to review, if in the process of review 3-4 consecutive test results are normal, then syphilis can be judged as a cure. However, if the RPR titer does not drop to the desired level after 3-4 weeks of treatment, it is necessary to repeat the treatment. Each patient’s situation is different, because the clinical stage of syphilis treatment is also different, so we recommend that patients consult their doctors according to their situation.