Wang is 16 years old, 170 cm tall, weighing 195 pounds, and is a sophomore in high school. Like other children, he is the apple of his parents’ eye, and they have high hopes for him. However, there is a problem that has always troubled him, so he has not been able to rest assured that his studies. It turns out that five years ago Xiao Wang suffered from a strange disease, the back of his neck, armpits, chest skin darkened, becoming very rough, some parts even appear protruding skin protrusions, touching like velvet, but the strange thing is that the darkened skin does not hurt or itch, but Xiao Wang’s grades began to decline, and can not concentrate in class. The first time Wang did not care, thought they would fade away after a while, but after several months, Wang’s skin never “white”. The company’s main business is to provide a wide range of products and services to its customers. The company’s main business is to provide a wide range of products and services to the public. It was not until they recently visited the expert clinic of Professor Qu of the Department of Endocrinology of Shanghai Tenth People’s Hospital that they discovered that Xiao Wang was suffering from a common but “mysterious” disease – acanthosis nigricans. What is acanthosis nigricans? The medical definition: acanthosis nigricans is a kind of hyperkeratosis, symmetrical velvet-like thickening of the skin, hyperpigmentation and even wart-like protrusion of the lesion, mainly involving the axillae, the back of the neck, the flexor surface of the skin, the groin and the umbilicus, etc., rarely involving the mucosal surface. Simply put, it is a darkening of the skin. The most common cause of acanthosis nigricans is obesity, so what are the criteria for determining obesity? At present, the more widely used clinical body mass index (BMI), that is, weight (kg)/height 2 (m), BMI greater than 25 is overweight, greater than 28 is obese, this paper patient Xiao Wang BMI is 33.73kg/m2, belongs to serious obesity. Wang is suffering from acanthosis nigricans, which is caused by obesity. It is found that the incidence of acanthosis nigricans in the general population is 7%, while in the obese population the incidence is 74%. Especially with the improvement of living conditions, adolescents drink carbonated beverages and eat sweets from childhood, there are more and more “little fatties” and the incidence of acanthosis nigricans is increasing. However, in recent years, many experts at home and abroad believe that acanthosis nigricans is a sign of insulin resistance, which means that if it is allowed to develop, patients will develop glucose metabolism disorders, hyperinsulinemia, insulin resistance, and even diabetes in the near future, and patients with acanthosis nigricans are often combined with fatty liver, abnormal liver function, hyperuricemia, polycythemia vera, and polycythemia vera. Patients with acanthosis nigricans are often combined with fatty liver, abnormal liver function, hyperuricemia, polycystic ovary syndrome and other metabolic problems. If left untreated, the consequences will be unimaginable. What should I do if I get acanthosis nigricans? Acanthosis nigricans is not a terrible disease, and it is not incurable. The key to treatment lies in removing the cause of the disease. For patients like Xiao Wang, it is to solve the problem of obesity. First of all, we should adjust the patient’s diet, mainly light diet, less greasy; secondly, we should actively participate in physical exercise, life is exercise; thirdly; supplemented with appropriate drugs, such as metformin, flavopiridol, etc. Then, as the weight decreases, acanthosis nigricans will also improve, while other metabolic disorders in the body will also improve. It has been found that in addition to hyperinsulinemia, patients with acanthosis nigricans are associated with various metabolic disorders such as non-alcoholic fatty liver disease, hyperuricemia, hyperlipidemia, subclinical hypothyroidism and cortisolism, which need to be treated actively at the same time. It can be seen that the darkening of the skin on the body surface may be a manifestation of acanthosis nigricans, a manifestation of hyperinsulinemia and metabolic abnormalities, which should never be taken lightly and can be prevented by timely treatment. Therefore, parents are advised to pay attention to over-eating, easily hungry obese children, if they find obvious darkening and pigmentation in the back of the neck, underarm or groin, etc., they should seek medical attention and timely treatment, so that our next generation will have a healthy body and a good mind.