This refers to chronic alcohol use that results in significant mental and physical impairment and severely affects social functioning. Chronic alcoholism is also an important factor in suicide, and these patients may have personality changes, sexual dysfunction, and various psychiatric symptoms, and are prone to infection and traumatic brain injury. Common neurological impairments include peripheral neuropathy, seizures, cerebellar damage, ataxia, optic nerve atrophy, and dementia. Nutritional disorders are common and can occur with cholecystitis, gastritis, gastric ulcers, myocarditis, renal cirrhosis and cirrhosis of the liver. Alcoholic cirrhosis is an important cause of death. Long-term alcohol consumption can cause fetal syndrome, which manifests as low weight, low intelligence and growth disorders. 1. Alcoholism-induced hallucinosis: It is a hallucinatory state caused by long-term alcohol consumption, mostly verbal or non-verbal hallucinations, hallucinations are often primitive or various small animal hallucinations. They occur mostly within 48 hours after the sudden cessation or significant reduction of alcohol consumption, and can also occur with continued alcohol consumption. They are not associated with impaired consciousness, euphoria, or vegetative hyperactivity. It may be followed by delusions and corresponding mood disorders and impulsive behavior. The duration of the illness is hours, days, or weeks, and usually does not exceed 6 months. 2. Alcoholism-induced delusional disorder: It is a delusional state caused by long-term alcohol consumption. The patient is clearly conscious, and delusions of jealousy or victimization are more common, often accompanied by corresponding emotional reactions and behaviors. The onset of the disease is slow and the course of the disease is migratory. Alcoholism-induced encephalopathy: It is a serious organic brain syndrome caused by long-term (usually more than 5 years) or heavy alcohol consumption, manifesting as acute delirium, memory deficits, personality changes or dementia. More commonly, Wernick’s encephalopathy is the sudden onset of delirium, somnolence, muscle twitching, ophthalmoplegia, denervation, or coma after a single episode of excessive alcohol consumption during a long period of time, which may turn into one of the following two syndromes upon sobriety: 1) Korsakoff’s syndrome (amnesia syndrome), which often occurs after one or more episodes of delirium tremens and is characterized by memory deficits (significant near-memory deficits with misconfiguration or Fictitious), and may have symptoms such as euphoria, naïveté, laziness, disorientation, etc. In severe cases, intelligence is reduced, and often accompanied by signs and symptoms such as peripheral neuritis. 2) Alcoholic dementia syndrome: slow onset, with severe personality changes, memory loss, and dementia. These patients have diminished or lost social functioning and the ability to cope with life. These 2 syndromes may also occur separately. 4. Personality changes: either as part of the above syndromes or with personality changes alone as the main manifestation.