Normal hemostasis is accomplished by blood vessels, platelets and coagulation mechanism, and more than ten coagulation factors of human body are produced by liver except one which is not synthesized in liver, therefore, no matter what causes liver injury, it will affect the coagulation function of human body. Only the severity is different and. Hepatitis B and C viral hepatitis and other viral infections tend to inhibit bone marrow hematopoiesis, which causes the spleen, which is involved in blood storage, to swell and become enlarged over time, resulting in thrombocytopenia, or a decrease in white and red blood cells. Platelet count is an important indicator of blood hemostasis and coagulation. Therefore, patients with liver damage accompanied by thrombocytopenia can experience a wide variety of bleeding, commonly bleeding from teeth, stomach bleeding, skin bruising, rarely bleeding from joints, bleeding from the urinary tract, bleeding from the lungs, bleeding from the brain, and so on. In healthy adults, the platelet count (PLT) is (100 ~ 300) × 109 /L, when the number of platelets decreases to 60 × 109 /L, there is a possibility of bleeding. Liver disease with thrombocytopenia patients in ordinary life and work in how to prevent it? 1, to develop the habit of eating soft food and light diet, in order to prevent rough, big and spicy food from damaging the blood vessels of esophagus and stomach and causing bleeding. Prevent constipation, pay attention to nutrition, and strengthen the resistance of the body. 2, serious liver disease, try to avoid taking drugs that affect platelet function, such as aspirin, dipyridamole, indomethacin, chemotherapy drugs and some antibiotics such as linezolid, vancomycin and so on. 3, skillful use of dietary therapy to regulate thrombocytopenia, such as jujube soup peanut kernels (coated), peanuts with garlic and so on. 4. Regularly check your own coagulation function and coagulation factor status, for patients with platelets (30 ~ 60) × 109 / L, there may be mild bleeding or post-surgical bleeding symptoms, avoid lifting heavy objects in daily life, avoid excessive force, under the guidance of the doctor, regular testing and regular treatment. For patients with platelets <30 × 109 / L, more serious bleeding or spontaneous bleeding will occur, so more special attention should be paid to rest, through drug therapy to raise platelets to a safe level, to ensure that the patient does not bleed to jeopardize the function of organs and even life, when drug therapy is ineffective, feasible surgical intervention. 5, usually keep the environment clean, fresh air, full sunlight, cut nails diligently, avoid scratching the skin. Pay attention to keep warm, prevent cold, prevent cross-infection.