Differential diagnosis of neck masses

  1.Acute lymphadenitis: the mass has redness, swelling, heat and pain.  2.Chronic lymphadenitis: The lymph nodes are enlarged about 0.5-1.0cm, soft in texture. Most of them have obvious foci of infection and are often confined lymph node enlargement, with pain and pressure, generally not more than 2-3 cm in diameter, and will shrink after anti-inflammatory treatment. Enlarged inguinal lymph nodes, especially flat lymph nodes that have been present for a long time without change, are mostly of no importance. However, enlarged cervical and supraclavicular lymph nodes with no obvious cause signify systemic lymphoid tissue proliferative diseases.  3. Lymph node tuberculosis: Most lymph nodes have low fever, and the enlarged lymph nodes are hard (fibrosis or calcification), the surface is not smooth, and the texture is not uniform (cheese-like changes), or cystic due to cheese-like necrosis, or adherent to the skin, poorly mobile, and may break down. They are often associated with pulmonary tuberculosis. These patients have positive tuberculin tests and blood antibodies to tuberculosis. The diagnosis is confirmed by multiple, multi-site lymph node puncture, smear and biopsy, and identification of the primary site of tuberculosis.  4.Nodular disease: Mostly seen in adolescents and middle-aged people, the lymph nodes are mostly within 2cm in diameter, and the texture is usually hard, non-fusing and not adherent to the skin. The lymph nodes are often invasive of bilateral lung hilum, radiating, and more than 90% of them have lung changes clinically, accompanied by long-term low fever. Lymph nodes may be enlarged throughout the body, especially in front of and behind the ear, under the jaw, and next to the trachea. There may be malaise, fever, night sweats, loss of appetite, and weight loss. It is clinically difficult to differentiate from malignant lymphoma. There may be hepatomegaly and/or splenomegaly, and the mediastinum and superficial lymph nodes are often invaded and enlarged. There may be leukopenia, anemia, and increased sedimentation during the active progressive phase. Serum globulin is partially elevated in about 1/2 of patients, with IgG elevation being the most common, and plasma albumin is decreased. Serum calcium is increased, serum uric acid is increased, and serum alkaline phosphatase is increased. Serum angiotensin-converting enzyme (SACE) activity is increased in the acute phase (normal value 17.6-34u/ml), which is diagnostically informative. Serum interleukin-2 receptor (IL-2R) and soluble interleukin-2 receptor (sIL -2R) are elevated, which has more important significance for the diagnosis of nodal disease.  5. Histiocytic necrotizing lymphadenitis: Mostly in young adults, sudden onset of high fever that does not subside or persistent low fever, often accompanied by upper respiratory symptoms, resembling influenza. The enlarged lymph nodes are often painful and indurated, and do not fuse with each other. White blood cells are often decreased. Pathological examination shows extensive coagulative necrosis of the lymph nodes surrounded by reactive histiocytic proliferation without neutrophil infiltration. The disease may resolve spontaneously within 1-2 months (spontaneous healing) and the prognosis is good . In most cases, the disease will improve on its own without special treatment. Symptomatic treatment can be combined with Chinese herbal medicine to reduce symptoms. In severe cases, glucocorticoids can be given in appropriate amounts. Antibiotic treatment is not effective.  6.Giant lymph node hyperplasia: Lymph node enlargement of unknown origin, invading the chest, mediastinum and the hilum and lung. The symptoms disappear after the mass is removed.  7.Metastatic lymph node cancer: hard texture, no pressure pain, inactive. It is mostly seen in the metastasis of nasopharyngeal cancer, lung cancer and gastrointestinal tumor.  8.Reactive lymphadenitis: When the body is subjected to trauma or disease or foreign antigen-induced emergency reaction, it will lead to reactive lymphadenitis. For example, certain drugs or biological products can cause fever, rash, lymph node enlargement, etc.. Those caused by common chemical drugs are called drug fever, such as methyldopa, isoniazid, phenytoin sodium and various vaccines; those caused by biological products are called serum sickness. All of these can cause swollen lymph nodes.