Overview of strain A. baumannii, also known as Acinetobacter baumannii, belongs to Gram-negative bacteria, is a strictly aerobic, non-lactose fermenting conditional pathogenic bacteria, is a common type of hospital infection. In recent years, due to the abuse of antibiotics, this bacterium has gradually developed drug resistance and become “multi-drug resistant Acinetobacter baumannii”, which is very difficult to treat. Intracranial infection with A. baumannii is a common complication in neurosurgery, and is one of the most serious diseases of the central nervous system. And if intracranial infection of Acinetobacter baumannii is present, it is a very serious condition and very difficult to treat. Acinetobacter baumannii itself is a drug-resistant bacterium, and it is very troublesome even if the infection is spread to other parts of the body. And if it is an intracranial infection, it is further difficult to treat because of the blood-brain barrier, and most of the general anti-infection treatment is ineffective. However, it is still possible to find the right place and use the right method to cure it. The treatment of intracranial infections is more complicated in neurosurgery, especially for some drug-resistant bacteria, such as Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa, etc. Conventional treatment is generally ineffective. The special treatment technology of cerebrospinal fluid department can treat intracranial infections well and achieve good results. At present, this technology has cured more than a thousand cases of acute and critical neurosurgical patients who were on the verge of death or disability after failing treatment in many top hospitals in China, and won good reputation from patients.