Intracranial infections are a common clinical complication and have been listed as one of the four major hospital infections (pulmonary, urinary, deep trauma incision, intracranial). The main intracranial infections are meningitis, encephalitis, and brain abscess. The pathogens may be bacteria, viruses, parasites, mycoplasma, chlamydia, mycobacteria, rickettsia, etc. In clinical practice, intracranial infections in the field of neurosurgery are mostly caused by trauma and post-surgery; hematogenous abscesses, parasitic diseases, sarcoidosis, and tuberculosis are also common. So what are the symptoms of intracranial infection, or what are the main clinical manifestations of intracranial infection? The early stage of intracranial infection is usually manifested as fever, headache, vomiting, impaired consciousness, neck tonicity, etc. The bacterial culture of cerebral crest fluid may be positive result, and there are many changes in cerebral crest fluid properties and laboratory tests. Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa (green pus) infection is mostly manifested as purulent cerebral crest fluid, and conventional anti-infection treatment is usually ineffective. Intracranial infections are very dangerous and should be treated early because once they develop into advanced stages of intracranial infections, brain parenchymal infections or even brainstem parenchymal infections occur, in which case the patient cannot be completely cured in most cases and may be disabled or even cause death. For the treatment of intracranial infections, it is especially important to choose an effective and correct effective method in a timely manner. Because there are many clinical examples of improper disposal of intracranial infections, resulting in patients who could have been cured eventually going to a terminal condition. Therefore, once intracranial infection occurs, one should choose to receive regular and correct specialist treatment of brain crest fluid in a professional hospital as early as possible to obtain complete recovery through systematic and effective means.