Intracranial infection is a more serious disease of the central nervous system, mostly caused by craniocerebral trauma and craniotomy, which can occur at any age, and this inflammatory disease can cause different degrees of damage to brain tissue and even the brain stem. In clinical practice, it is found that patients with intracranial infections will have symptoms such as weakness, drowsiness, fever, limb pain, etc., and patients with acute onset of the disease will also suffer from convulsions, mental abnormality, mental retardation, aphasia and hemiparesis, or even coma, which makes intracranial infections very dangerous, and if the condition is delayed due to the delay of treatment, the infection area will be expanded, which will lead to disability or death. Therefore, patients with intracranial infections must receive effective treatment in a timely manner. Even though it is a very dangerous and complex disease, most patients with intracranial infections can be relieved and recovered as long as they receive effective treatment. After many years of clinical practice, Cerebrospinal fluid neurosurgery has gradually summarized a set of Cerebrospinal fluid specialized integrated therapy in the treatment of intracranial infections. In this set of therapies, there is a specialized treatment for intracranial infections, which can effectively inhibit the invasion of pathogenic bacteria on brain tissues and brainstem. Now, through this set of integrated therapy, many life-threatening intracranial infections of critically ill patients have been saved. In this set of therapies, the patient’s therapeutic effect or clinical outcome is mainly taken as the criterion for the success or failure of the surgery. In addition to the treatment of intracranial infections, it can also be a good solution for the infections after hydrocephalus shunt, and it is good at the treatment of spontaneous hydrocephalus, pediatric hydrocephalus, secondary hydrocephalus caused by traumatic brain injury, cerebral hemorrhage, etc., and it can minimize the occurrence of intracranial infections.