In neurosurgery, many diseases require craniotomy for treatment. Craniotomy is a kind of invasive treatment, and this invasive operation will make the brain tissue or cremaster, which is originally protected by the scalp, skull and meninges, communicate with the outside world, resulting in the opportunity for pathogenic bacteria to take advantage of it, so that the outside pathogenic bacteria may have the opportunity to enter the skull and cause intracranial infection. In fact, not only craniotomy, but also ventricular drainage, lumbar pool drainage, ventriculoperitoneal shunt and other invasive operations may cause intracranial infections. Especially for many patients with hydrocephalus, sometimes the treatment period may be longer and the chance of postoperative infection may be higher. The common pathogenic bacteria of intracranial infections are mostly gram-positive cocci, but in recent years, with the application of a variety of high-level antibiotics and the problem of “clinical abuse” caused by people’s excessive fear of intracranial infections, the intracranial infections that were originally quite curable have developed into drug-resistant bacteria that are difficult to cure, or even incurable, and some people can be infected with Some people will be infected with some “super drug-resistant bacteria” or fully drug-resistant bacteria, for which common clinical antibiotics are ineffective. What is the treatment plan for postoperative intracranial infections? The treatment of postoperative intracranial infections is not only an anti-inflammatory and antiseptic process, but also a comprehensive and systematic medical project. For patients with different types of intracranial infections, different primary diseases, different complications, and different physical conditions of patients, etc., a complete set of systematic and complete treatment plan is needed, which needs to be carefully organized and implemented, and various problems may be encountered during the implementation process and the plan needs to be adjusted and optimized immediately to achieve faster and better treatment results.