Intracranial infections usually occur when the patient’s body resistance is weakened, and some viruses, bacteria, fungi, etc. take advantage of the situation to invade the central nervous system, resulting in intracranial infections. Different patients, the site of infection and pathogens are different, the manifestation of symptoms are also very different. Symptoms of intracranial infection are complex and varied In clinical practice, encephalitis, meningitis, brain abscess caused by intracranial infection is very likely, and intracranial infection in the field of neurosurgery is mostly caused by trauma and post-surgery; according to the relevant data show that the incidence of intracranial infection after craniotomy is as high as 0.20% to 27.59%. The clinical symptoms of intracranial infections are complex and varied, which can be manifested as fever, headache, vomiting, as well as impaired consciousness and cervical rigidity. The diagnosis of intracranial infection is based on the fact that symptoms alone cannot accurately determine whether or not an infection has occurred in the skull, but should be evaluated in detail with other tests. In clinical practice, intracranial infection can be diagnosed when cerebrospinal fluid examination shows white blood cell (WBC) >0.01X109/L, with predominantly increased multinucleated cells, and cerebrospinal fluid bacterial culture is positive. For patients who have been diagnosed, it is recommended to go to the hospital as soon as possible for relevant treatment, otherwise it will bring many serious consequences to their health. At present, there is a set of clinical characteristics of diagnosis and treatment technology, for different intracranial infection patients, to formulate personalized diagnosis and treatment plan, to achieve good results.