Coffee has become the first world class beverage after tea, more and more white-collar workers and students have the habit of drinking coffee. I’m sure we’ve all heard of coffee’s refreshing effects, but have you heard many “experts” say that drinking coffee is addictive and does no good at all? For a long time, research on coffee and the risk of disease is endless, and a recent study by the Institute of Hepatobiliary and Pancreatic Research at Zhengzhou University can bring a new perspective to everyone. Recently, the Institute of Hepatobiliary and Pancreatic Research of Zhengzhou University uncovered the key role of coffee in the risk of gallstone formation through a study led by Associate Professor Yuling Sun, and the research team published the latest research results in the internationally renowned academic journal “Alimentary Pharmacology and Therapeutics”. Systematic review with meta-analysis: coffee consumption andthe risk of gallstone disease”. The results of this study provide a comprehensive assessment and analysis of eight studies on coffee consumption and the risk of gallstone formation, as well as a dose-response relationship study. The data from these trials suggest that coffee consumption is effective in reducing the risk of gallstones by 17%, and for the first time, a decreasing trend in the risk of gallstones was observed with increasing coffee consumption. This study provides an important scientific basis for primary prevention of gallstones. Under the guidance of Associate Professor Yuling Sun, the hepatobiliary and pancreatic research team at Zhengzhou University searched the database for all population-based cohort studies and high-quality case-control studies related to the risk of gallstones, and carefully screened the retrieved literature to identify one case-control study, and five (encompassing seven independent studies) prospective population-based cohort studies. The total sample size of the population included in this study was 227,749, including 11,477 gallstones cases. The study suggested that an additional 1 cup of coffee per day was associated with a 5% reduction in the risk of gallstones, while for those who consumed 2, 4, and 6 cups of coffee per day, the reduction in the risk of gallstones corresponded to 11%, 19%, and 25%. The mechanism of gallstone formation is extremely complex, and coffee contains thousands of components. Caffeine in coffee may contribute to the reduction in gallstone formation, but the exact mechanism needs to be further investigated; trace elements contained in coffee may also be involved in the mechanism. There is no completely effective way to prevent the formation of gallstones, and this study provides a perspective for new ideas in this field, while more scholars will delve into coffee, a drink that can be found everywhere, to play more new roles for human use. Finally, I remind you that coffee is good, but do not greedy cup oh.