It is not recommended for depressed patients to take a long-term leave of absence, especially for mild to moderate depression, it is recommended to keep working with the disease. The ultimate goal of depression treatment is to restore the patient’s social function to normal, or not to affect the patient’s social function, which means that the patient can live, study, work and socialize normally, which is also helpful for the recovery of the disease. In case of severe depression, patients need to take leave from work during the acute period and need 24-hour supervision by family members to prevent self-injury and suicide, as well as to observe the adverse effects of medication and adjust the dose of medication so that the depressant can exert this antidepressant effect. However, after the acute phase of major depressive disorder, the symptoms are more stable, it is still recommended to go to work or school.