Headache is one of the most common clinical symptoms. There is no one who has not experienced a headache. Headache is only a clinical symptom and not a separate disease. Many, many diseases can cause headache, such as encephalitis, cold, migraine, etc. Headache is often accompanied by a certain emotional response, the degree of which varies widely between individuals. In other words, some people tolerate a certain level of illness, while others have a significant reaction. So what are the causative factors associated with headaches? What kind of relationship does it have? The answers to these questions are the main concern of many headache patients. 1.Physical factors: Headache is caused by inflammation, injury or swelling of pain-sensitive tissues inside and outside the cranium (1) Traction, extension or displacement of blood vessels: Headache occurs when traction or displacement of blood vessels inside the cranium. (ii) Increased intracranial pressure: cerebral edema, venous sinus thrombosis, hydrocephalus, cerebral tumor or cerebral cystic worm compression blockage affecting cerebrospinal fluid circulation, etc. (3) Decreased intracranial pressure: sometimes after lumbar puncture or lumbar anesthesia, due to more cerebrospinal fluid loss, intracranial pressure decreases, causing headache due to intracranial venous sinus and vein dilation or traction. (2) Vascular dilation: Various causes of intracranial and extracranial arterial dilation can produce headache. For example, in acute intracranial and extracranial infections, pathogenic toxins can cause arterial dilation; metabolic diseases such as hypoglycemia, hypercapnia and hypoxia; toxic diseases such as carbon monoxide poisoning and alcoholism can cause headache due to intracranial and extracranial vasodilation. (3) Stimulation of meninges: Headache occurs due to stimulation of meninges or traction of meninges by cerebral edema due to intracranial inflammatory exudates such as meningitis or blood stimulation of meninges from hemorrhagic diseases, such as subarachnoid hemorrhage. (4) Contraction of head and neck muscles: Headache caused by continuous contraction of head and neck muscles is called tension headache. It can be divided into two categories: one is primary, the cause of which is unknown, and the headache is caused by continuous contraction of head and neck muscles, called tension headache; the other is symptomatic, due to reflex cervical muscle tension contraction caused by neck diseases, such as cervical spondylolisthesis, neck trauma or cervical disc lesion, etc. (5) Nerve irritation or lesion: cranial nerve and cervical nerve compression lesion or inflammation, such as trigeminal neuritis, occipital neuritis, tumor compression. Cranial nerve irritation lesions such as trigeminal neuralgia, etc. (6) Involvement headache: lesions in the eyes, ears, nose, paranasal sinuses, teeth, and neck can spread or reflect to the head and face, producing involvement headache. (2) Biochemical factors: Biochemical factors are currently receiving high attention. In recent years, through the study of migraine, it was found that norepinephrine, 5-antelope tryptamine, bradykinin and prostaglandin have obvious changes in the blood of patients with recurrent migraine. For example, the release of norepinephrine can cause vasoconstriction; 5-antelope tryptophan, if free in the plasma, can cause large blood vessels to constrict and small blood vessels to dilate. When migraine attacks occur, the reduction of 5-antelope tryptamine facilitates the action of bradykinin on cerebral blood vessels and produces a sterile inflammatory response, thus causing headache. In addition, histamine can also cause headache by dilation of intracranial blood vessels. 3.Endocrine factors From many clinical cases, we can see that the relief and attack of headache are closely related to endocrine. For example, migraine is mostly seen in women, the first attack is often in adolescence, and there is a tendency that the headache is good during menstruation, relieved during pregnancy and stopped during menopause. Tension headache is often aggravated during menstruation and menopause. 4.Neuropsychiatric factors Mainly due to various stimuli in the external environment, the patient produces anxiety, anxiety and other results.