Endocrine disorders are one of the major causes of male infertility and must be given adequate attention. The endocrine diseases related to male infertility are as follows: abnormal testicular endocrine lesions: primary testicular hypofunction, more common are Kline felter syndrome, radiation damage, cytotoxic damage, malnutrition, etc.; secondary testicular hypofunction, such as Kallmam’s syndrome, androgen receptor deficiency manifested by male pseudohermaphrodite androgen receptor deficiency, etc. Adrenal gland diseases: Addison””s disease, Cushing’s syndrome, feminized adrenal cortical tumors, congenital adrenal hyperplasia, aldosteronism and other diseases can cause male infertility. Thyroid disorders: Severe hypothyroidism or hyperthyroidism can affect reproductive function. In hypothyroidism, testosterone synthesis is reduced, sperm production is inhibited, and sexual dysfunction occurs. Hyperthyroidism is often accompanied by gynecomastia, hypoactive libido, and impotence. Pituitary lesions: Hyperpituitary gland function may cause increased libido and body shape changes in the early stages, followed by hypoactive libido, semen abnormalities, impotence, etc. and lead to infertility. Hypopituitarism, such as pituitary tumors, inflammation, surgical injury or radiotherapy, can damage the pituitary gland, resulting in hypopituitarism, decreased libido and intercourse ability, testicular atrophy, and impaired sperm production. Pituitary tumors can increase the level of prolactin in blood, interfere with the secretion of LH and inhibit the spermatogenic function of testes and impotence, thus leading to male infertility.